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磁场控制微流体具有诸多优点,如设计简单、易于操作、对温度和pH值等不敏感,在微流控芯片中具有较好的发展前景。在微流控芯片中磁场主要是通过永磁体、电磁体和软磁体来产生,对这三种磁场产生方式进行了综述。根据磁体位置或磁体形式又可将每种方式分为不同的类型,并对一些典型的加工方法进行列表对比。使用永磁体产生磁场的装置具有结构简单和磁场强度大等优点,但装置的集成度较低;使用电磁体产生磁场的装置具有磁场强度可控、集成度较高等优点,但其磁场强度较弱;使用软磁体产生磁场的装置具有集成度较高、磁场强度较大等优点,但需要与外置磁体配合使用,在实际应用中应根据具体情况选择磁场产生方式。最后对未来微流控领域内磁场控制技术的发展方向进行了展望。
Abstract：Magnetic manipulation of microfluidics has many advantages,such as simple design,easy operation,insensitivity to temperature and pH value,etc.,so it has a good development prospect in microfluidic chips.In microfluidic chips,the magnetic field are mainly generated by permanent magnets,electromagnets and soft magnets,and three kinds of generation methods of magnetic field are reviewed.According to the magnet position or the magnet form,each method can be divided into different types,and some typical processing methods are compared in a list.The devices that use permanent magnets to generate magnetic field have simple structures and high magnetic field intensities,but its integration level is low;the devices that use electromagnets to generate magnetic field have controllable magnetic field intensities and high integration,but the magnetic field intensity is weak;the devices that use soft magnets to generate magnetic field have high integration and high magnetic field intensities,but they needs to be used with external magnets.In the application,the generation methods of magnetic field should be selected according to the specific needs.Finally,the future development directions of magnetic manipulation in microfluidic field are prospected.
[1] MANZ A,GERBER N,WIDMER H M.Miniaturized total chemical analysis systems:a novel concept for chemical sensing[J].Sensors and Actuators:B,1990,1(1/2/3/4/5/6):244-248.
[2] MARK D,HAEBERLE S,ROTH G,et al.Microfluidic lab-ona-chip platforms:requirements,characteristics and applications[J].Chemical Society Reviews,2010,39(3):1153-1182.
[3] YANG R J,HOU H H,WANG Y N,et al.Micro-magnetofluidics in microfluidic systems:a review[J].Sensors and Actuators,2016,B224:1-15.
[4] YIN H,MARSHALL D.Microfluidics for single cell analysis[J].Current Opinion in Biotechnology,2012,23(1):110-119.
[5] ZHU H W,LIN X G,SU Y,et al.Screen-printed microfluidic dielectrophoresis chip for cell separation[J].Biosensors and Bioelectronics,2015,63:371-378.
[6] KLEINSTREUER C,LI J,KOO J.Microfluidics of nanodrug delivery[J].International Journal of Heat and Mass Transfer,2008,51(23):5590-5597.
[7] SERSHEN S R,MENSING G A,NG M,et al.Independent optical control of microfluidic valves formed from optomechanically responsive nanocomposite hydrogels[J].Advanced Materials,2005,17(11):1366-1368.
[8] TAN S H,SEMIN B,BARET J.Microfluidic flow-focusing in AC electric fields[J].Lab on a Chip,2014,14(6):1099-1106.
[9] WIXFORTH A.Acoustically driven planar microfluidics[J].Superlattices and Microstructures,2003,33(5/6):389-396.
[10] GRANT K M,HEMMERT J W,WHITE H S.Magnetic field-controlled microfluidic transport[J].Journal of the American Chemical Society,2002,124(3):462-467.
[11]王大鹏．机械合金化制备纳米复合永磁材料及其磁性能研究[D]．大连：大连理工大学，2014.
[12] GIJS M A M.Magnetic bead handling on-chip:new opportunities for analytical applications[J].Microfluid Nanofluid,2004,1(1):22-40.
[13]刘春婷．磁场作用下微流体混合行为的数值分析和实验研究[D]．武汉：华中科技大学，2019.
[14] PAMME N.Magnetism and microfluidics[J].Lab on a Chip,2006,6(1):24-38.
[15]王誉，中村元．稀土永磁材料的研究现状与发展[J]．稀土信息，2018,415(10):38-41.
[16]李鑫．永磁体空间磁场分布规律及其在传感器中的应用[D]．南京：南京师范大学，2015.
[17] PAMME N,EIJKEL J C T,MANZ A.On-chip free-flow magnetophoresis:separation and detection of mixtures of magnetic particles in continuous flow[J].Journal of Magnetism and Magnetic Materials,2006,307(2):237-244.
[18] NOURI D,ZABIHI-HESARI A,PASSANDIDEH-FARD M.Rapid mixing in micromixers using magnetic field[J].Sensors and Actuators:A,2017,255:79-86.
[19] HUANG N T,HWONG Y J,LAI R L.A microfluidic microwell device for immunomagnetic single-cell trapping[J].Microfluidics and Nanofluidics,2018,22(2):16-1-16-8.
[20] KYE H G,PARK B S,LEE J M,et al.Dual-neodymium magnet-based microfuidic separation device[J].Scientific Reports,2019,9:9502-1-9502-10.
[21] LOMBARDI D,DITTRICH P S.Droplet microfluidics with magnetic beads:a new tool to investigate drug-protein interactions[J].Analytical and Bioanalytical Chemistry,2011,399(1):347-352.
[22] ZHANG J,YAN S,YUAN D,et al.A novel viscoelasticbased ferrofluid for continuous sheathless microfluidic separation of nonmagnetic microparticles[J].Lab on a Chip,2016,16(20):3947-3956.
[23] HEJAZIAN M,NGUYEN N T.Magnetofluidic concentration and separation of non-magnetic particles using two magnet arrays[J].Biomicrofluidics,2016,10(4):044103-1-044103-11.
[24] WU J,CUI Y W,XUAN S H,et al.3D-printed microfluidic manipulation device integrated with magnetic array[J].Microfluidics and Nanofluidics,2018,22(9):1-11.
[25] ZHOU R,SURENDRAN A N,MEJULU M,et al.Rapid microfluidic mixer based on ferrofluid and integrated microscale NdFeB-PDMS magnet[J].Micromachines,2020,11(1):29-45.
[26] LIU Y J,GUO S S,ZHANG Z L.Integration of minisolenoids in microfluidic device for magnetic bead-based immunoassays[J].Journal of Applied Physics,2007,102(8):4911-4918.
[27] WEN C Y,YEH C P,TSAI C H,et al.Rapid magnetic microfluidic mixer utilizing AC electromagneticfield[J].Electrophoresis,2009,30:4179-4186.
[28] CENEV Z,ZHANG H B,SARIOLA V,et al.Manipulating superparamagnetic microparticles with an electromagnetic needle[J].Advanced Materials Technologies,2018,3(1):1700177-1-1700177-9.
[29] SMISTRUP K,HANSEN O,BRUUS H,et al.Magnetic separation in microfluidic systems using microfabricated electromagnets—experiments and simulations[J].Journal of Magnetism and Magnetic Materials,2005,293(1):597-604.
[30] RAMADAN Q,SAMPER V D,PUIU D P,et al.Fabrication of three-dimensional magnetic microdevices with embedded microcoils for magnetic potential concentration[J].Journal of Microelectromechanical Systems,2006,15(3):624-638.
[31] RAMADAN Q,SAMPER V D,POENAR D P,et al.An integrated microfluidic platform for magnetic microbeads separation and confinement[J].Biosensors and Bioelectronics,2006,21(9):1693-1702.
[32] JIANG J H,LI Y,HUANG H M,et al.Fabrication and thermal features of a novel microdevice—a microchannel surrounded by a microsolenoid[C]//Proceedings of 3rd International Conference on Bioinformatics and Biomedical Engineering.Beijing,China,2009:1-4.
[33] SIEGEL A C,SHEVKOPLYAS S S,WEIBEL D B,et al.Cofabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane)[J].Angewandte Chemie,2006,118(41):7031-7036.
[34] PLOUFFE B D,LEWIS L H,MURTHY S K.Computational design optimization for microfluidic magnetophoresis[J].Biomicrofluidics,2011,5(1):013413-1-013413-22.
[35] PLOUFFE B D,MAHALANABIS M,LEWIS L H,et al.Clinically relevant microfluidic magnetophoretic isolation of rare-cell populations for diagnostic and therapeutic monitoring applications[J].Analytical Chemistry,2012,84(3):1336-1344.
[36] DEREC C,WILHELM C,SERVAIS J,et al.Local control of magnetic objects in microfluidic channels[J].Microfluid Nanofluid,2014,8:123-130.
[37] BU M,CHRISTENSEN T B,SMISTRUP K,et al.Characterization of a microfluidic magnetic bead separator for highthroughput applications[J].Sensors and Actuators:A,2008,145/146:430-436.
[38] YU X,FENG X,HU J,et al.Controlling the magnetic field distribution on the micrometer scale and generation of magnetic bead patterns for microfluidic applications[J].Langmuir,2011,27(8):5147-5156.
[39] LIN Y A,WONG T S,BHARDWAJ U,et al.Formation of high electromagnetic gradients through a particle-based microfluidic approach[J].Journal of Micromechanics and Microengineering,2007,17(7):1299-1306.
[40] MELANIE A,GASSNER A L,MORANDINI J,et al.Magnetic track array for efficient bead capture in microchannels[J].Analytical and Bioanalytical Chemistry,2009,395(3):747-757.
[41] ZHOU R,WANG C.Microfluidic separation of magnetic particles with soft magnetic microstructures[J].Microfluidics and Nanofluidics,2016,20(3):1-11.
[42] ZHANG R Q,HONG S L,WEN C Y,et al.Rapid detection and subtyping of multiple influenza viruses on a microfluidic chip integrated with controllable micro-magnetic field[J].Biosensors and Bioelectronics,2018,100:348-354.
[43] OH S S,QIAN J R,LOU X H,et al.Generation of highly specific aptamers via micromagnetic selection[J].Analytical Chemistry,2009,81(13):5490-5495.
[44] SALIBA A E,SAIAS L,PSYCHARI E,et al.Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays[J].Proceedings of the National Academy of Sciences,2010,107(33):14524-14529.
[45] XIA J K,CHEN X H,ZHOU C Z,et al.Development of a low-cost magnetic microfluidic chip for circulating tumour cell capture[J].IET Nanobiotechnology,2011,5(4):114-120.
[46] YU X,WEN C Y,ZHANG Z L,et al.Control of magnetic field distribution by using nickel powder@PDMS pillars in microchannels[J].RSC Advances,2014,4(34):17660-17666.
[47] SUN C,HASSANISABER H,YU R,et al.Paramagnetic structures within a microfluidic channel for enhanced immunomagnetic isolation and surface patterning of cells[J].Scientific Reports,2016,6(1):29407-1-29407-9.
基本信息:
DOI：10.13250/j.cnki.wndz.2020.10.008
中图分类号:TN492
引用信息:
[1]马秀清,孙凯欣,范一强.磁控微流控芯片中磁场产生方式的研究进展与应用[J].微纳电子技术,2020,57(10):810-817+822.DOI:10.13250/j.cnki.wndz.2020.10.008.
2020-09-17
2020-09-17