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针对微流体的研究现状,介绍了微流体的驱动与控制原理,将其分为电动控制技术和非电动控制技术。然后,分析了电动微流体的控制模型及数值模拟方法的类型,重点介绍了基于宏观方程的连续介质力学法、基于介观模拟的格子Boltzmann方法、基于微观运动的分子动力学方法和多种方法耦合的多尺度模拟等方法的原理、分类和特点以及在电动微流体研究中的应用现状。结合2D和3D微通道内流体参数、电场参数等的模拟结果,阐述了以上几种数值模拟方法的优缺点,指出了电动微流体数值模拟技术的发展方向和研究重点,对于微流体的理论研究和微流控器件的优化设计具有一定指导意义。
Abstract：Aiming at the research status of microfluids,the actuating and controlling principles of microfluids are introduced.The control techniques are classified as the electrokinetic and non-electrokinetic control techniques.The governing model and numerical simulation methods of the electrokinetic microfluid are analyzed.The principles,sorts and characteristics of the continuum medium mechanics method based on the macroscopic equation,lattice Boltzmann method based on the mesoscopic simulation,molecular dynamics method based on the microscopic locomotion and multiscale simulation method based on the coupling of multiplicate methods,and their applications in electrokinetic microfluids are presented emphatically.Considering the results of the flow field and electric field parameters in 2D and 3D microchannels,the merits and shortcomings of several numerical simulation methods are illuminated.The progress directions and research emphases of the numerical simulation in electrokinetic microfluids are pointed out,which provide a guide for the theory research in microfluids and optimization design in microfluidic devices.
[1]方肇伦.微流控分析芯片[M].北京:科学出版社,2003:5-15.
[2]方肇伦.微流控分析芯片的制作及应用[M].北京:化学工业出版社,2005:1-30.
[3]冯焱颖,周兆英,叶雄英,等.微流体驱动与控制技术研究进展[J].力学进展,2002,32(1):1-16.
[4]KIRBY BJ,HASSELBRINKJ R.Zeta potential of microfluidic substrates:1.Theory,experi mental techniques,and effects on separations[J].Electrophoresis,2004,25(2):187-202.
[5]章莉娟,郑忠.胶体与界面化学[M].广州:华南理工大学出版社,2006:5-15.
[6]BARZ P J D,ZADEH H F,MEISELI,et al.Use of elec-trokinetic phenomena in microfluidic devices[C]//Procee-dings of the Sixth International ASME Conference on Nanochannels,Microchannels and Minichannels.Darmstadt,Germany,2008:1791-1798.
[7]李清岭,陈令新.微流体驱动与控制技术[J].化学进展,2008,20(9):1406-1415.
[8]NGUYEN N T,WERELEYS T.Fundamentals and applica-tions of micro fluidics[M].Boston:Artech House,2002.
[9]ZHANG C S,XI NG D A,LI Y Y.Micropumps,micro-valves,and micromixers within PCR microfluidic chips[J].Biotechnol Adv,2007,25(5):483-514.
[10]I VERSON B D,GARI MELLA S V.Recent advances in mi-croscale pumping technologies:a review and evaluation[J].Microfluid Nanofluid,2008,5(2):145-174.
[11]KARNI ADAKIS G E,BESKOK A,ALURU N.Microflows and nanoflows:fundamentals and si mulation[M].New York:Springer Science+Business Media,Inc,2005.
[12]HU G,LI D.Multiscale phenomena in microfluidics and nano-fluidics[J].Chem Eng Sci,2007,62(13):3443-3454.
[13]杨大勇.微流控芯片中电渗流输运特性研究[D].南昌:南昌大学,2009.
[14]CHANG C C,YANG RJ.Electrokinetic mixing in microfluidic systems[J].Microfluid Nanofluid,2007,3(5):501-525.
[15]PATANKAR N A,HU H H.Numerical si mulation of elec-troosmotic flow[J].Analytical Chemistry,1998,70(9):1870-1881.
[16]LI D.Electrokinetics in micro fluidics[M].Burlington,MA:Elsevier Academic Press,2004.
[17]YANG C,LI D.Analysis of electrokinetic effects on the liquid flowin rectangular microchannels[J].Colloids Surf:A,1998,143(2/3):339-353.
[18]ERICKSON D,LI D.Analysis of alternating current electroos-motic flows in a rectangular microchannel[J].Langmuir,2003,19(13):5421-5430.
[19]ERICKSON D,LI D.Influence of surface heterogeneity on electrokinetically driven microfluidic mixing[J].Langmuir,2002,18(5):1883-1892.
[20]徐征,黎永前,刘冲,等.微通道壁面突起对片上电泳分离流动特性影响数值计算研究[J].计算力学学报,2007,24(1):25-29.
[21]REN L,LI D.Electro-osmotic flowin heterogeneous micro-channels[J].J Colloid and Interface Sci,2001,243(1):255-261.
[22]ERMAKOVS V,JACOBSONS C,RAMSEYJ M.Computer si mulations of electrokinetic transport in microfabricated chan-nel structure[J].Anal Chem,1998,70(21):4494-4505.
[23]姜洪源,杨胡坤,王扬.直流电渗流在微通道内的控制与仿真研究[J].微纳电子技术,2008,45(3):166-169.
[24]YANG RJ,FU L M,HWANG C C.Electroosmotic entry flowin a microchannel[J].J Colloid Interface Sci,2001,244(1):173-179.
[25]FU L M,YANG R J,LEE G B.Analysis of geometry effects on band spreading of microchip[J].Electrophoresis,2002,23(4):602-612.
[26]BI ANCHI F,FERRIGNO A,GIRAULT H H.Finite ele-ment si mulation of an electroosmotic driven flowdivision at a T-junction of microscale di mensions[J].Anal Chem,2000,72(9):1987-1993.
[27]MITCHELL MJ,QIAO R,ALURU N R.Meshless analysis of steady-state electroosmotic transport[J].Journal of MEMS,2000,9(4):435-449.
[28]SOUDERS D,KHAN I,YAO G F,et al.A numerical model for si mulation of combined electroosmotic and pressure driven flow in microdevices[J].Journal of Visualization,2004,7(2):167-170.
[29]GLATZEL T,LITTERST C,CUPELLI C,et al.Compu-tational fluid dynamics(CFD)software tools for microfluidic applications-a case study[J].Computers&Fluids,2008,37(3):218-235.
[30]杨大勇,刘莹.电渗驱动微流道内流场的数值模拟[J].系统仿真学报,2009,21(11):3199-3202.
[31]YANG D Y,LI U Y.Numerical si mulation of electroosmotic flow in microchannels with sinusoidal roughness[J].Colloids Surf:A,2008,328(10):28-33.
[32]CHEI N R,CHEN H,LI AO C.Analysis of electro-kinetic pumping efficiency through finite-length nano-scale surface-charged capillaries[J].J Electroanal Chem,2009,630(1/2):1-9.
[33]江涛.基于MEMS技术的直流电渗流微泵的研究[D].哈尔滨:哈尔滨工业大学,2006.
[34]刘晓为,田丽,霍明学,等.集成毛细管电泳芯片的设计[J].传感器技术,2003,22(2):61-64.
[35]田丽,刘晓为,王喜莲,等.毛细管电泳芯片的模拟设计与实验研究[J].微纳电子技术,2003,40(7/8):340-343.
[36]SUKOP MC,THORNE D T.Lattice Boltzmann modeling-an introduction for geoscientists and engineers[M].Verlag Berlin Heidelberg:Springer,2007:15-50.
[37]何雅玲,李庆,王勇,等.格子Boltzmann方法的工程热物理应用[J].科学通报,2009,54(18):2638-2656.
[38]LI B M,KWOK D Y.Alattice Boltzmann model for elec-trokinetic microchannel flow of electrolyte solution in the presence of external forces with the Poisson-Boltzmann equation[J].Int J Heat Mass Transfer,2003,46(22):4235-4244.
[39]TI AN F Z,LI B M,KWOK D Y.Si mulation of electroos-motic flows in micro-and nanochannels using a lattice Boltz-mann model[J].J Comput Theor Nanosci,2004,1(4):417-423.
[40]LI B M,KWOK D Y,Lattice Boltzmann model of microflui-dics inthe presence of external forces[J].J ColloidInterface Sci,2003,263(1):144-151.
[41]WANG J,WANG M,LI Z.Lattice Poisson-Boltzmannsi mula-tions of electroosmotic flows in microchannels[J].J Colloid Interface Sci,2006,296(2):729-736.
[42]WANG M,WANGJ,CHENS,et al.Electrokinetic pum-ping effects of charged porous media in microchannels using the lattice Poisson-Boltzmann method[J].J Colloid Inter-face Sci,2006,304(1):246-253.
[43]WANG D,SUMMERS J L,GASKELL P H.Modelling of electrokinetically driven mixing flow in microchannels with patterned blocks[J].Computers and Mathematics with Applications,2008,55(7):1601-1610.
[44]WANG M,WANGJ,CHENS.Roughness and cavitations effects on electroosmotic flows in rough microchannels using the lattice Poisson-Boltzmann methods[J].Journal of Com-putational Physics,2007,226(1):836-851.
[45]HLUSHKOU D,KANDHAI D,TALLAREK U.Coupled lattice-Boltzmann andfinite difference si mulation of electroos-mosis in microfluidic channel[J].Int J Num Meth Fluids,2004,46(5):507-532.
[46]GUO Z L,ZHAO T S,SHI Y.Alattice Boltzmann algo-rithmfor electro-osmotic flows in microfluidic devices[J].J Chem Phys,2005,122(8):144907-1-144907-10.
[47]KANG J F,HEO H S,SUH Y K.LBM si mulation on mixing enhancement by the effect of heterogeneous zeta-po-tential in a microchannel[J].Journal of Mechanical Science and Technology,2008,22(6):1181-1191.
[48]郭照立.格子Boltzmann方法的原理及应用[M].北京:科学出版社,2009:1-10.
[49]文玉华,朱如曾,周富信,等.分子动力学模拟的主要技术[J].力学进展,2003,33(1):65-73.
[50]陈小燕.纳米通道内流体的分子动力学研究[D].合肥:中国科学技术大学,2008.
[51]QIAO R,ALURU N R.Transient analysis of electroosmotic flowin nano-diameter channels[J].Modeling and Si mula-tion of Microsystems,2002,2(1):28-31.
[52]陈敏,陈云飞,仲武,等.纳米通道中离子输运机理的分子动力学仿真[J].中国科学E辑:技术科学,2009,39(2):249-255.
[53]田菲,陈云飞.纳米通道中电渗流的分子动力学模拟[J].功能材料与器件学报,2008,14(2):288-292.
[54]张鑫杰,倪中华.纳米粒子介电泳的分子动力学模拟[J].东南大学学报(自然科学版),2008,38(5):884-888.
[55]刘更,刘天祥,张征,等.宏观-微观多尺度数值计算方法研究进展[J].中国机械工程,2005,16(16):1493-1499.
[56]HU G,LI D.Multiscale phenomena in microfluidics and nano-fluidics[J].Chem Eng Sci,2007,62(13):3443-3454.
[57]NIE X B,CHENS Y,EWN,et al.Acontinuumand mo-lecular dynamics hybrid methodfor micro-and nano-fluidflow[J].J Fluid Mech,2004,500(4):55-64.
[58]李玉秀,徐进良.分子动力学与连续介质力学耦合模型的研究及应用[J].自然科学进展,2005,15(12):1426-1435.
[59]冀封.微流控多尺度现象研究[D].吉林:吉林大学,2008.
基本信息:
中图分类号:O361.4
引用信息:
[1]杨大勇.电动微流体数值模拟研究进展[J].微纳电子技术,2010,47(09):552-559.
基金信息:
国家自然科学基金资助重点项目(50730007);; 江西省教育厅科学技术研究资助项目(GJJ10071)
2010-09-15
2010-09-15