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综述了近年来国内外关于微纳米机器人在肿瘤治疗领域的研究进展。首先介绍微纳米机器人及其驱动方式，归纳每种驱动方式的优势、局限及适用场景，从细胞/亚细胞的尺寸和优异的运动性能两方面论述微纳米机器人在肿瘤药物精准递送中具备的独特优势，并从逆血流主动运动、增强高渗透长滞留(EPR)效应和突破生物屏障的角度展开分析。重点阐述了微纳米机器人在化学治疗、光学治疗、免疫治疗、栓塞治疗等肿瘤传统疗法和新兴疗法中的治疗原理、作用机制及应用前景，在此基础上提出微纳米机器人在肿瘤治疗领域当前面临的挑战及应对策略，并对未来的发展方向进行了展望。
Abstract：The research progress of micro-nanorobots in the field of tumor therapy at home and abroad in recent years is reviewed. Firstly, micro-nanorobots and their driving methods are introduced, then the advantages, limitations and application scenarios of each driving method are summarized. The unique advantages of micro-nanorobots in precise delivery of tumor drugs are discussed from two aspects of cell/subcellular size and excellent motion performance, and the analyses are carried out from the perspective of anti-blood flow active motion, enhanced permeability and retention(EPR) effect and breakthrough of biological barriers. The therapy principles, action mechanisms and application prospects of micro-nanorobots in traditional and emerging tumor therapies such as chemotherapy, optical therapy, immunotherapy, and emboliolotherapy are highlighted. On this basis, the current challenges and countermeasures of micro-nanorobots in the field of tumor therapy are proposed, and the future development directions are envisaged.
[1] SUNG H,FERLAY J,SIEGEL R L,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA:A Cancer Journal for Clinicians,2021,71(3):209-249.
[2] YAN X H,ZHOU Q,VINCENT M,et al.Multifunctional biohybrid magnetite microrobots for imaging-guided therapy[J].Science Robotics,2017,2(12):eaaq1155-1-eaaq1155-14.
[3] CHEN Y D,PAN R J,WANG Y,et al.Carbon helical nanorobots capable of cell membrane penetration for single cell targeted SERS bio-sensing and photothermal cancer the-rapy[J].Advanced Functional Materials,2022,32(30):2200600-1-2200600-10.
[4] CALVO-MARZAL P,SATTAYASAMITSATHIT S,BALASUBRAMANIAN S,et al.Propulsion of nanowire diodes[J].Chemical Communications,2010,46(10):1623-1624.
[5] XIAO Z Y,DUAN S F,XU P Z,et al.Synergistic speed enhancement of an electric-photochemical hybrid micromotor by tilt rectification[J].ACS Nano,2020,14(7):8658-8667.
[6] de áVILA B E,ANGELL C,SOTO F,et al.Acoustically propelled nanomotors for intracellular siRNA delivery[J].ACS Nano,2016,10(5):4997-5005.
[7] XU T L,SOTO F,GAO W,et al.Ultrasound-modulated bubble propulsion of chemically powered microengines[J].Journal of the American Chemical Society,2014,136(24):8552-8555.
[8] ZOU X B,ZHENG Q,WU D,et al.Controllable cellular micromotors based on optical tweezers[J].Advanced Functional Materials,2020,30(27):2002081-1-2002081-10.
[9] XUAN M J,WU Z G,SHAO J X,et al.Near infrared light-powered Janus mesoporous silica nanoparticle motors[J].Journal of the American Chemical Society,2016,138(20):6492-6497.
[10] LIN Z H,GAO C Y,WANG D L,et al.Bubble-propelled Janus gallium/zinc micromotors for the active treatment of bacterial infections[J].Angewandte Chemie International Edition,2021,60(16):8750-8754.
[11] CHOI H,JEONG S H,KIM T Y,et al.Bioinspired urease-powered micromotor as an active oral drug delivery carrier in stomach[J].Bioactive Materials,2022,9:54-62.
[12] AKOLPOGLU M B,ALAPAN Y,DOGAN N O,et al.Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery[J].Science Advances,2022,8(28):eabo6163-1-eabo6163-14.
[13] BUSS N,YASA O,ALAPAN Y,et al.Nanoerythrosome-functionalized biohybrid microswimmers[J].APL Bioengineering,2020,4(2):026103-1-026103-7.
[14] AKOLPOGLU M B,DOGAN N O,BOZUYUK U,et al.High-yield production of biohybrid microalgae for on-demand cargo delivery[J].Advanced Science,2020,7(16):2001256-1-2001256-10.
[15] XU H F,MEDINA-SáNCHEZ M,MAITZ M F,et al.Sperm micromotors for cargo delivery through flowing blood[J].ACS Nano,2020,14(3):2982-2993.
[16] ALAPAN Y,BOZUYUK U,ERKOC P,et al.Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow[J].Science Robotics,2020,5(42):eaba5726-1-eaba5726-11.
[17] GU H R,HANEDAN E,BOEHLER Q,et al.Artificial microtubules for rapid and collective transport of magnetic microcargoes[J].Nature Machine Intelligence,2022,4(8):678-684.
[18] MENG X,XU Y R,LU Q B,et al.Ultrasound-responsive alkaline nanorobots for the treatment of lactic acidosis-mediated doxorubicin resistance[J].Nanoscale,2020,12(25):13801-13810.
[19] CHEN W J,JIANG R H,SUN X,et al.Self-fueled Janus nanomotors as active drug carriers for propulsion behavior-reinforced permeability and accumulation at the tumor site[J].Chemistry of Materials,2022,34(16):7543-7552.
[20] GWISAI T,MIRKHANI N,CHRISTIANSEN M G,et al.Magnetic torque-driven living microrobots for increased tumor infiltration[J].Science Robotics,2022,7(71):eabo0665-1-eabo0665-15.
[21] KIEVIT F M,ZHANG M Q.Cancer nanotheranostics:improving imaging and therapy by targeted delivery across biological barriers[J].Advanced Materials,2011,23(36):H217-H247.
[22] WANG W,WU Z G,LIN X K,et al.Gold-nanoshell-functionalized polymer nanoswimmer for photomechanical poration of single-cell membrane[J].Journal of the American Chemical Society,2019,141(16):6601-6608.
[23] ZHANG H Y,LI Z S,GAO C Y,et al.Dual-responsive biohybrid neutrobots for active target delivery[J].Science Robotics,2021,6(52):eaaz9519-1-eaaz9519-16.
[24] WAN M M,CHEN H,WANG Z D,et al.Nitric oxide-driven nanomotor for deep tissue penetration and multidrug resistance reversal in cancer therapy[J].Advanced Science,2021,8(3):2002525-1-2002525-12.
[25] XU L H,ZHANG K X,MA X,et al.Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation[J].Journal of Nanobiotech-nology,2022,20(1):429-1-429-18.
[26] LI X S,LOVELL J F,YOON J,et al.Clinical development and potential of photothermal and photodynamic therapies for cancer[J].Nature Reviews Clinical Oncology,2020,17(11):657-674.
[27] YANG P P,ZHAI Y G,QI G B,et al.NIR light propulsive Janus-like nanohybrids for enhanced photothermal tumor therapy[J].Small,2016,12(39):5423-5430.
[28] CHOI H,LEE G H,KIM K S,et al.Light-guided nanomotor systems for autonomous photothermal cancer therapy[J].ACS Applied Materials & Interfaces,2018,10(3):2338-2346.
[29] GAO C Y,LIN Z H,WANG D L,et al.Red blood cell-mimicking micromotor for active photodynamic cancer therapy[J].ACS Applied Materials & Interfaces,2019,11(26):23392-23400.
[30] CAO S P,SHAO J X,WU H L,et al.Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy[J].Nature Communications,2021,12(1):2077-1-2077-10.
[31] CHEN S Q,SUN X,FU M M,et al.Dual-source powered nanomotor with integrated functions for cancer photo-theranostics[J].Biomaterials,2022,288:121744-1-121744-10.
[32] CEVAAL P M,ALI A,CZUBA-WOJNILOWICZ E,et al.In vivo T cell-targeting nanoparticle drug delivery systems:considerations for rational design[J].ACS Nano,2021,15(3):3736-3753.
[33] MERIC-BERNSTAM F,LARKIN J,TABERNERO J,et al.Enhancing anti-tumour efficacy with immunotherapy combinations[J].The Lancet,2021,397(10278):1010-1022.
[34] CHEN H,SHI T,WANG Y,et al.Deep penetration of nanolevel drugs and micrometer-level T cells promoted by nanomotors for cancer immunochemotherapy[J].Journal of the American Chemical Society,2021,143(31):12025-12037.
[35] ZHOU J R,KARSHALEV E,MUNDACA-URIBE R,et al.Physical disruption of solid tumors by immunostimulatory microrobots enhances antitumor immunity[J].Advanced Materials,2021,33(49):2103505-1-2103505-12.
[36] FOLKMAN J.Tumor angiogenesis:therapeutic implications[J].The New England Journal of Medicine,1971,285(21):1182-1186.
[37] LI S P,JIANG Q,LIU S L,et al.A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo[J].Nature Biotechnology,2018,36(3):258-264.
[38] LAW J,WANG X,LUO M X,et al.Microrobotic swarms for selective embolization[J].Science Advances,2022,8(29):eabm5752-1-eabm5752-12.
[39] GO G,YOO A,NGUYEN K T,et al.Multifunctional microrobot with real-time visualization and magnetic resonance imaging for chemoembolization therapy of liver cancer[J].Science Advances,2022,8(46):eabq8545-1-eabq8545-19.
[40] de áVILA B E,RAMíREZ-HERRERA D E,CAMPUZANO S,et al.Nanomotor-enabled pH-responsive intra-cellular delivery of caspase-3:toward rapid cell apoptosis[J].ACS Nano,2017,11(6):5367-5374.
[41] FU Q R,FENG H J,LIU L T,et al.Spatiotemporally controlled formation and rotation of magnetic nanochains in vivo for precise mechanotherapy of tumors[J].Angewandte Chemie International Edition,2022,61(51):e202213319-1-e202213319-9.
[42] JI J F,MA F,ZHANG H B,et al.Light-activatable assembled nanoparticles to improve tumor penetration and eradicate metastasis in triple negative breast cancer[J].Advanced Functional Materials,2018,28(33):1801738-1-1801738-14.
[43] DAHMANI F Z,ZHONG D,QI Y C,et al.A size-tunable and multi-responsive nanoplatform for deep tumor penetration and targeted combinatorial radio-/chemotherapy[J].Journal of Materials Chemistry:B,2019,7(29):4484-4498.
[44] LIU F Y,LI X,LI Y Y,et al.Designing pH-triggered drug release iron oxide nanocomposites for MRI-guided photothermal-chemoembolization therapy of liver orthotopic cancer[J].Biomaterials Science,2019,7(5):1842-1851.
[45] ZHONG D,LI W L,QI Y C,et al.Photosynthetic bio-hybrid nanoswimmers system to alleviate tumor hypoxia for FL/PA/MR imaging-guided enhanced radio-photodynamic synergetic therapy[J].Advanced Functional Materials,2020,30(17):1910395-1-1910395-11.
基本信息:
DOI：10.13250/j.cnki.wndz.2023.06.001
中图分类号:R730.5;TP242
引用信息:
[1]庞世尧,鄢晓晖.微纳米机器人在肿瘤治疗领域的研究进展[J].微纳电子技术,2023,60(06):811-819.DOI:10.13250/j.cnki.wndz.2023.06.001.
基金信息:
国家自然科学基金青年基金项目(82001845); 广东省机器人与智能系统重点实验室开放基金(XDHT2019588A); 深圳市科技创新委员会基础研究面上项目(JCYJ20190809163407481)
2023-06-13
2023-06-13
2023-06-13